Dr. Umesh A. Kshirsagar

Assistant Professor

1D-509, POD Building
Email: uakshirsagar[at]iiti.ac.in
Phone: +91 0731 660 3218

Group Website

Research Interests

Development of Novel Synthetic Methodology

‘Synthetic functionalization that creates new Carbon-Carbon and Carbon-Heteroatom bonds are one of the important transformations in organic chemistry, as they enable the design of artificial chemical structures essential to modern life.’

A] Photo-redox Catalysis: A single-electron oxidation of organic substrate is one of the potential concepts to generate versatile radical intermediate. Consequently, visible light photo-redox catalysis is of great attention not only to the alternative for a photochemical and electrochemical reaction but also for classical synthetic methods. We are working on photo-redox catalysis for the development of various bond-forming reactions and their applications in novel molecule synthesis.

B] C-H Activation: We intend to develop chemo- and regio-selective metal-catalyzed C-H bond activation reactions to create new C-C and C-Heteroatom bonds.

C] Oxidative Coupling & Cross Dehydrogenative Coupling: Our research is also focused to develop metal-catalyzed and/or Photo-redox catalyzed Oxidative Coupling and Cross Dehydrogenative Coupling (CDC) reactions that meet most of the demands of an ideal synthesis. Under Oxidative CDC conditions, two weak C-H bonds are coupled in a direct manner (without any pre-adjustment requirements) by a metal catalyst and/or Photo-redox catalyst.

D] Total Synthesis of Natural Products: The efficiency of any novel synthetic reaction is measured by its successful application in the synthesis of structurally attractive and biologically important natural products. We have planned to lead our methodologies to make progress in achieving the development of efficient and reliable routes to construct biologically active natural molecules as well as interesting lead molecules for drug synthesis.

E] Green Chemistry:

Selected Publications

  • Pd‐Catalyzed Decarboxylative Ortho‐Aroylation of 2‐Aryl‐quinazolinone Comprising Intrinsic Directing Group with α‐Oxocarboxylic Acids    D. S. Waghmare, S. D. Tambe, U. A. Kshirsagar* Asian J. Org. Chem., 2020, 9. 2095-2098.
  • Regioselective Coupling of 2-Arylquinazolinone C-H with Aldehyde and Benzyl Alcohol under Oxidative Condition U. A. Kshirsagar*, D. S. Waghmare, S. D. Tambe.  New J. Chem., 2020, 44, 16697-16701.
  • Metal Free Synthesis of 3-Thiocyanatobenzothiophenes via Eosin Y Photoredox Catalysed Cascade Radical Annulations of 2-alkynylthioanisoles. S. D. Tambe, M. S. Jadhav, R. S. Rohokale, and U. A. Kshirsagar* Euro. J. Org. Chem. 2018, 4867-4873.